The Sodium Potassium Pump – Nutrition and the Brain

The daily dietary choices we make go far beyond impacting our physical health. They also have a significant effect on our short-term and long-term cognitive health, and ultimately may even factor into how we think and behave. However, before we can look at the major role that good nutrition has on the health of our brains, we first need to know the difference between our brains and our minds.

Difference Between Our Brains and Our Minds

Our Brain

Our brains are the working process of our consciousness minds, which is connected to a network of 85 to 100 billion neurons in our brains. These neurons are connected to billions of other neurons that control every cellular function in our bodies. What’s amazing is that all of these neurons transfer messages of thought that are created in our minds beyond the physical world by chemical neurotransmitters. These messages of thought are delivered and stored in our unconscious mind bodies and produce our repeated patterns of life and our daily habits.

Our Mind

Just how powerful is this process of our minds to use our brains to create and store these messages that control us on a moment-to-moment basis that determines our neurological us? Our neurological us is our personalities and our personality traits we share and express to the world, and that world responds back to us and confirms who we are and who we are becoming neurologically. Keep in mind, our neurological self-drives 95% of our unconscious program self by sending messages back up to our brains so we can act without thinking; nerve and the brain-body connection. This huge and daunting task is assisted by our nutrition, opening more chemical channels to release more neurotransmitters.

What are Neurotransmitters?

In order for neurons, or nerve cells, to send messages throughout the body, they need to be able to communicate with one another. However, neurons are not simply connected to one another. A small gap, called the synaptic cleft, separates each neuron. Thus, a chemical messenger is needed to relay signals between neurons. It is neurotransmitters that are the chemical messenger that carry signals between neurons and other cells in the body through a process called neurotransmission, ultimately allowing communication to take place between neurons.

The neurotransmitters that get released in the brain can affect an array of psychological and physiological functions; including mood, learning, concentration, appetite, sleep, and heart rate. Neurotransmitters are so important that neurotransmitter imbalances are thought to be associated with Alzheimer’s disease and Parkinson’s disease, as well as psychiatric illnesses such as depression and schizophrenia.

Scientists have discovered more than 60 molecules that meet the criteria for being classified as a neurotransmitter.

Some of the best-known neurotransmitters include:

• Acetylcholine: a very widely distributed excitatory neurotransmitter that triggers muscle contraction and stimulates the excretion of certain hormones. In the central nervous system, it is involved in wakefulness, attentiveness, anger, aggression, sexuality, and thirst.
• Dopamine: involved in controlling movement and posture. It also modulates mood and plays a central role in positive reinforcement and dependency.
• GABA (gamma-aminobutyric acid): contributes to motor control, vision, and many other cortical functions. It also regulates anxiety.
• Glutamate: is associated with learning and memory.
• Histamine: plays a role in metabolism, temperature control, regulating various hormones, and controlling the sleep-wake cycle.
• Norephinephrine: is important for attentiveness, emotions, sleeping, dreaming, and learning. Norepinephrine is also released as a hormone into the blood, where it causes blood vessels to contract and heart rate to increase.
• Serotonin: contributes to various functions, such as regulating body temperature, sleep, mood, appetite, and pain

How Neurotransmitters Communicate Signals from Neuron to Neuron

For neurons to communicate with one another, neurotransmitters must be released from one neuron and bind to another neuron. In doing so, signals are relayed from neuron to neuron, which ultimately allows our thoughts, behaviors, and bodily functions to be expressed.

In order for neurotransmitters to be released from neurons in the brain, an electrical impulse, called an action potential, must be generated.  This electrical impulse allows for neurotransmitters to cross the synaptic cleft. Once neurotransmitters cross the synaptic cleft, they bind to receptors on another neuron.  The neurotransmitters act like a key and the receptor site act like a lock. It takes the right key to open specific locks. If the neurotransmitter is able to work on the receptor site, it triggers changes in the receiving cell. This results in messages being relayed from one neuron to another.

In order for the electrical impulse to be activated that triggers the release and transport of these neurotransmitters, an electrical gradient must be maintained in each cell. The sodium potassium pump is the mechanism responsible for maintaining this electrical gradient, doing so by pumping two potassium ions into the cell and pumping out three sodium ions, ultimately leading to the interior of the nerve cell being slightly more negative than the exterior.  This creates the conditions for an electrical signal to travel. Without this proper functioning of the sodium potassium pump, nerve cells will not function and neurotransmitters will not be released in appropriate amounts, as an imbalance of sodium and potassium will result in either too many or too few neurotransmitters will be released.

How Our Diet Impacts the Sodium Potassium Pump

The functioning of the sodium potassium pump is greatly impacted by our diet, as we consume both of these minerals through the foods that we eat.

The Dietary Guidelines for Americans recommends that both adults and children limit sodium intake to 2,300 mg- which is about one teaspoon of salt. However, the average American consumes 3,400 mg of sodium on daily basis! Furthermore, only 3% of Americans consume the recommended 4,700 mg of potassium per day, with most Americans consuming just about half of this recommendation.

This over-consumption of sodium and under-consumption of potassium is associated with many health risks; including high blood pressure, stroke, obesity, and heart disease. Furthermore, this excess sodium intake and deficient potassium intake can also lead to sub-optimal functioning of the sodium potassium pump, thereby leading to weaker nerve impulses, which results in fewer neurotransmitters being released in the brain.

Thus, it is no surprise that researchers are now correlating high sodium diets with memory and concentration problems. Furthermore, as neurotransmitters play a role in dictating emotional state, any influence that weakens neurotransmitter could affect our emotions as well.

Therefore, it is important that we balance our sodium and potassium intake. Doing so helps to ensure that the electrochemical gradient in each neuron will be optimally maintained, leading to stronger electrical signals in the brain and a greater release of neurotransmitters, ultimately resulting in not only an improved physical state, but also an improved cognitive state.

What Should I Eat to Positively Impact the Sodium Potassium Pump?

So how do we balance our sodium and potassium intake? Well, the answer is really quite simple- minimize processed foods! While most people generally correlate adding salt to a meal while cooking or after it is prepared as the culprit for the overconsumption of sodium, this is not the case. Rather, the culprit of Americans’ overconsumption of sodium is salt that is added during the preparation of processed foods, which is a staple of the American diet. Restaurant food and drinks, even items such as sweet blended coffee drinks, doughnuts, and cookies all contain high amounts of sodium.

On the other hand, a daily diet consisting of two-thirds unprocessed plant foods and one-third unprocessed animal foods will only provide you with around 600 mg of sodium. In fact, it would seem nearly impossible to consume more than 1,200-1,500 mg of sodium per day from unprocessed foods!

Additionally, consuming a diet high in unprocessed plant foods will result in naturally higher potassium intake, as potassium is found in abundance in many plant foods. Some of the best sources of potassium are bananas, potatoes, prunes, oranges, beans and tomatoes.

While many people tend look for a quick fix to maintaining sodium-potassium balance through supplementing, this is not recommended. Most people get more than enough sodium through their normal diet. Furthermore, while overconsumption of potassium is rare, it can occur via overdosing with potassium supplements, which can have dangerous side effects.

Final Thoughts… The Sodium Potassium Pump – Nutrition and the Brain

The daily choices we make have health consequences that impact both our physical and cognitive wellbeing. The small decisions we make on a daily basis add up. Overtime, consistently making the choice to opt for the convenience of processed foods over more nutritious whole food can impact our memory, concentration, and mood- and may even go so far as to factoring in to how our neurological-self is expressed.

Weight Loss Success Stories : Brian with top weight loss client

This road traveled of weight loss success stories wasn’t traveled alone. From day one to current time, I was blessed with the love and friendship of many. Therefore, I wanted to say thanks to all that have loved and supported not only myself, but also my family and my business. Keep in mind that I could write a whole book on each of these great and wonderful people.

Each one of you, I will take a piece of what you have all given to me, and hold it next to my heart for the rest of my life. You are all great and wonderful mentors, friend and humanitarians and without just one of you my family and business wouldn’t be the same since  each one of you have shaped and molded me into the person I am today. Their weight loss success stories are truly inspirational.

Success Story # 1

Your Training Program Saved My Life

“Brian, as you and anyone that really knows me – I am a man of little words. When I was first introduced to you and your program, I thought to myself…’if this kid can produce a fraction of what I’ve been hearing about him, for me, I’d be amused.’ Since I’ve known you over these many years – you have turned my amusement into admiration and respect. You and your program did not impact my life. It actually saved my life. You are truly a man of great action, and it has been my pleasure to watch you save so many other lives. My family and my business all thank you for giving me back my life.”

James F. Little, Chairman/President & CEO, Employers Direct

The sea parted when you came into my life. Isn’t it magical how one little dollar-mailer changed my life forever by bringing you to me. I will never forget the day when you pulled me aside and said that I had developed a very special health and wellness program, and that I needed to double the amount I was charging. And also that I needed to focus on the clients whom would appreciate the health benefits from my services. Not only did you advise me on this next step, but also you took the time to educate and direct me toward a whole new business.

You taught me how trust my own ideas and thoughts, and not to worry about what other thought or said about me. What I appreciate and admire most about you is that you have never been afraid to reprimand me when you saw me going astray. How can I ever thank you enough for the overwhelming support and friendship that you have given to my business, my family, and me? It is important to us that you know that we truly love you, my dear friend.

Success Story # 2

A Truly Life Changing Experience

“Who would have ever guessed that meeting one man could change the rest of my life? Brian Theiss of TheissCare was truly a life changing experience not only for me, for my family and friends. For those of you who are committed to maximizing your life potential and receiving results in 60 days, what it take others to achieve in 1 year!! I recommend TheissCare: I know it sounds too good to be true, but I am walking proof of what the Brian Theiss program can do.”

Drew Donen, professional auctioneer, President/Owner of “Bang The Gavel”

I will never forget the first day I met you. As I opened the door to your Bentley, you preceded to my office with grace and confidence radiating from you. For the full hour, as you sat in front of me, you watched and critiqued my every move and words, without ever being negative. After raising my blood pressure, you looked me in the eye and said: “I will never do your program for myself”.

It took me several years to fully understand why you did do my program. I now realize that you did this for me. Maybe this was your way of giving back to society, by supporting this young kid who was trying so hard to support himself, his business, and his family. I can’t thank you enough for all the love, support, and the incredible people you have brought me over the years. Thank you for giving so much to us without every asking for anything in return, and I mean never asking for anything! We love you from the bottom of our hearts, our friend and family member.

Success Story # 3

Happier, Healthier and Enjoying Life

“I turned 46, and it happened! I started gaining weight and losing my health. But I am a stickler for efficiency, so when Brian told me if I would give  him three hours per week, he would give me two more hours per day back: and he did it. I can now do things I haven’t been able to do for decades. I am happier, healthier and enjoy life more. Thank you Brian.”

Greg Mooers, life-coach and motivational speaker

I wish I had met you 20 years ago. The impact you had on my personal life was swift and unexpected, and I still am in the process of truly understanding the long-term effect. You taught me many critical life lessons.

The first was: we can never truly be authentic when we live our lives from the outside in. And lesson number two: living our lives from the inside out is the only way to be a true hero.

I realize these two life lessons will take me the rest of my natural life to learn. But that is OK, since I will have my great friend and mentor to help me walk this hero’s path. I want to thank you from the inside out for all that you have done for me, my family, and business. We all love you so very much.

Success Story # 4

Raising the Bar on My Own Fitness

“I have practiced critical care medicine for over 30 years dealing with many ‘train wrecks’. Several years ago I refocused my medical practice to concentrate on highly personalized proactive health care. Now I concentrate on ‘fixing the tracks’. Evidence based data reveals that 70% of chronic health problems can be prevented. I have come to appreciate the importance of proper nutrition combined with a regular fitness program. The highly personalized fitness approach at TheissCare under the leadership of Brian Theiss is World Class. I am personally thankful to Brian for ‘raising the bar’ on my own fitness level and that of numerous patients.”

Dr. Paul Block, MD. FACP, FCCP

It still amazes me that one man can have such a profound impact on not only the health of so many people, but also on their personal lives. You are truly a man who puts his patients first, and for the past 35 years of practice. I wanted to thank you again for not only taking good care of my clients, but also for believing in my ability to serve my clients with the same care, love, and respect that you do.

I am so pleased to be able to work with you over these many years, and I am truly excited over what we will do together in the future. I have so much more to learn from you, my dear friend. On a personal note, thank you for all that you have done for me, and thank you for bringing me into your family and your heart. From my family to yours, we all love you very much.

Success Story # 5

A “Younger” Older Man

“What you have assembled for me, and many others, is a doable, practical conceptual framework and how to approach health and well-being by integrating a measured and segmented training and exercise program combined with a diet management approach. When followed with a measure of diligence and intensity, this program has enabled me to reach back to my younger years for that sense of vitality that has me eagerly anticipating what I will do in my coming years, as ‘a younger’ older man.”

Dr. David Lacey, Senior VP, research head, Amgen

Boy, were they ever right about you. When I was first told about you, I was told what a wonderful, brilliant person and scientist you are. As I got to know you better I realized that they also left out what a powerful man you are, and also what an exceptional friend you are, too.

What I have learned from you, my dear friend, David, is the knowing that in life’s struggles, if we use our energy correctly, we can change the world in which we live. You are a great and honorable man, and I want to thank you personally for giving so much to so many around the world. Thank you, my dear friend, for what you have given my business, my family and me. I love you very much.

Success Story # 6

Positive Encouragement

“Brian is the most knowledgeable health and fitness consultant I have ever met: not your average health and fitness consultant. Brian’s focus extends to wellness, medical history and current health status, as well as a clients energetic state. His positive encouragement and is happy demeanor only enhances his talents.”

Billy Yamaguchi, celebrity stylist, Feng Shui Beauty

The day I met you, the sun was shining and it continues to shine ever brighter in my heart. Out of all the people whom I have known and worked with through these 30+ years in business, you are the closest that comes to my inner self. When I am in your presence, you instantaneously bring out of me this incredible peace and balance that relaxes me to my core.

Thank you so much for bringing more of my internal energy out so I can help more of those around me. Billy, it is because of what you have given me, that I will be able to help so many more: You are brilliant! I want you to always remember that even though you are the artist and superstar Billy Yamaguchi to the world, you will also be Billy Picasso to me! Thanks for bringing me into you world and your heart.

Success Story # 7

Transforming People

“’We are going to do greatness together!’ These were the very first words that Brian Theiss uttered in our first handshake! His passion, purpose and sincere heartfelt interest in people is legendary, and he shined his light and gift on me form that moment on. It is said that ‘knowledge is power’ but when it is combined with heart, you have a master. Brian embodies this mastery in his expertise in transforming people from overweight, tired and out of shape to glowing beings who are truly empowered. I know, he put me on his program and I am more alive today than I ever have been. I am honored to call him my health advisor and colleague but more importantly, I am blessed to call him my friend.”

Freddie Ravel, #1 recording artist and composer

The man behind the music. The first night we met, I knew there was something special about you. As I got to know you over the years, I understood why you are truly respected and loved by so many, not only in the music industry, but also by everyone around you. You have reinforced in me the knowledge that it is all about the details, and it is up to us to structure the life we want, not only for ourselves, but also for those around us.

Thank you so much for taking my business and my family into your heart. This is truly a great gift. I am so excited about what we will do together in the future, since you are part of the great future of my life. I am excited about the thousands of lives that, together, we will touch. From my family to yours, we love you all.

How We Live is How We Die. Obesity is the most significant contributor to increased health problems.

Little known to most people, the last official disease-free American died in 1951! Hard to believe, but true. By the time we die, all of us will have one or more diseases. Disease is how we die. Indeed, Americans are dying from premature illness in ever-greater numbers. The primary causes: ignorance and denial of hidden health issues.

Welcome to the world of budding boomer awareness! Given all the changes in our current world, two outcomes are still inevitable – higher taxes (to fund the health care system that America’s unhealthy trend will require) and premature death (for an aging population in deep denial). The most important question facing politicians and the health care industry is how long can we dismiss these “facts of life”… or more accurately, facts of death.

How We Die

It’s not “if”, but “when” will each of us contract our first irreversible medical condition. By the time we feel the pain that signals serious organic disease, it is often too late. I see it every day – individuals who are overweight, out of shape, taking medications – still announcing to the world they are healthy. There’s a name for this condition… D-E-N-I-A-L! Denial is how we die.

Denial

Denial is a strange phenomenon, and like all delusions, denial’s aftermath is always painful… and usually shocking. Someone once wrote, “Those who danced were thought to be quite insane by those who could not hear the music.” Those of us who do not hear and heed the music of our bodies will stop dancing long before those who do.

While talking recently with an engaging friend of mine, he posed a probing question: “Is it true,” he asked, “that if we know our genetics, we can predict our death date?” The answer is somewhat complicated. Yet, if we can measure both our genetic predispositions and measure the impact of our lifestyle choices, it is true that we CAN reasonably predict our death date. Go online and google “life predictor” and fill in the numbers!

Lifestyle Choices

Poor lifestyle choices will hasten our deaths. Science now suggests that lifestyle is the number one killer known to man. We read that heart disease, cancer, and prescription drugs are the biggest killers in the United States, yet these death threats are all by-products of lifestyle choices – primarily poor nutrition and lack of exercise. Our lifestyle determines how we die.

From even a corporate perspective, there’s a bottom line benefit connected to health issues. Improving company health and fitness levels can strategically boost performance, thus trimming both the waistline and expenses in the workplace. A magazine article stated,

“Currently 20% of Americans have high blood pressure, 105 million Americans have high cholesterol, and there are 800 thousand new cases of adult-onset diabetes a year, plus 65% of Americans are overweight or obese.”

How we die… Our lifestyles are killing us!

These are shocking numbers. The article continues,

“Obesity is an epidemic in our country and requires dramatic attention be given its adverse effects. Statistics show obese individuals have 30-50% more chronic health issues versus those who smoke and drink heavily. More than smoking or drinking, obesity is now considered the most significant contributor to increased health problems and rising health care costs in the U. S.”

The article proposed that companies begin to manage their executives’ and employees’ personal health. You can bet, in our current economic environment, if individuals don’t manage their own health, the insurance companies will.

Having worked in the health and fitness field all my adult life, I am well aware of these facts of modern life. I am well aware of how we die. The bad news is: all of us are born with genetic time bombs of illness and death wired into our systems. The good news is: 80% to 90% of all premature illness is preventable by daily lifestyle choices. But the news is even better! The science of how we die and how the body responds to its environment has advanced so much over the past 50 years that even those born with dispositions to succumb to premature illness can outlive their genetic time bombs by making conscious lifestyle choices and engaging in healthy habits.

Genetics Loads the Gun, but Lifestyle Pulls the Trigger

We now have what no generation before us has ever had – the knowledge of how life can trump disease and premature death. Think about that. We are living in the first era in history where it is possible to enjoy disease-free lives! To control how we die. This knowledge may sound theoretical – to you, but not to me. Over the last 25 years, I’ve transformed my life and the lives of thousands. In truth, I’ve actually saved hundreds of lives. Yours may be next. This is your introduction to that process.

Brian with Dr. Paul Block, MD. FACP, FCCP

I currently serve a business and professional clientele. For years I trained amateur and professional athletes (major league baseball, hockey, cycling, and other sports), but I shifted the focus of my work… and for a very specific reason. The tipping point was when I realized that aging was a choice, and I recognized how the importance of commitment affected that choice. My goal was to not only help, but to save as many lives as possible. It broke my heart to witness so many young people, including athletes, losing their health due to poor lifestyle choices. More and more, I am seeing clients in their 30’s, 40’s, and 50’s contracting degenerative diseases that I used to help my clients in their 70’s and 80’s to overcome. I have devoted my life to those who are committed to reversing the causes of premature illness and death. Generally, it takes a more mature person to live a healthy life.

Brian with Lou Ferrigno, Actor, Author, “Mr. Universe”

In longevity, as in business, commitment is vital. I am witness to what made many successful in their professional endeavors – many, masters of their crafts. They are people who demand results and refuse mediocrity. They are always looking for the highest return on their investments. Such people can apply this same skill-set to their health. As someone said, most of us dig our graves with our forks and knifes! Many successful people have learned the hard way that neglecting proper diet and exercise will ensure a poor return on life’s most important investment… health.

Sustainable Self Discipline

At TheissCare, we develop Sustainable Self Discipline — what some clients call a medical miracle. This Sustainable Self Discipline achieves simply unbelievable results. For years, I have worked with the medical community on a daily basis, and thanks to our scientifically measurable outcomes, I can’t count the number of doctors that send us their patients and come to me for their own health. TheissCare is a first in the history of health, actually bridging the gap between traditional medicine and the health and fitness industry. That is why I have a proven track record with clients from all over the world.

What Makes TheissCare Unique and Different? 

My approach to preventing premature aging and illness and is to build a comprehensive program for each client that generates unprecedented and measurable results. Our programs are clinically proven and are based on a solid foundation of science. To achieve this, I measure and record every aspect of a client’s metabolism and hormonal balance throughout the process, using the latest scientific equipment. Today, TheissCare is the most comprehensive non-medical health and fitness program in the country. The results we produce in 60 days exceed what our competitors produce in 12 months.

My staff and I are committed to giving back to our clients the health they have lost along their life path. We focus on key components that determine how long a client will live and the quality of his or her life. To do this, I use a controlled, private environment and work with every individual in a unique way. I am also able to work with each client virtually, wherever in the world they may be, through my online fitness, mentor, monitor and personal training program.

The 3 Factors

The three components we measure are: metabolism, lipolysis and homeostasis. It took many years of study to truly grasp the full significance of these three factors. I know them first hand — through my own rehab and my work with thousands of clients. We do personal research and scientific testing for everyone who enrolls at TheissCare. We design a unique program for each individual, specifically formulated to meet their needs, based on their metabolic start point. Our client files offer astounding statistical proof of improvements in every measurement category and are simply too numerous to list.

How We Live

Health is now a runaway political and economic issue. Every week it seems like we are being presented with increasingly gloomy news. The U.S. health care system is predicted to bankrupt the nation within our lifetimes. If obesity continues at the same rate that it’s rising today, our system will run out of money within 15 years! And obesity is only one issue. One out of every three Americans will die of heart disease, and their treatment will cost taxpayers (that means all of us!) $260 billion every year.

Investing in Our Health

Generally, it takes a more mature person to live a healthy life. Truly successful people understand that the key investment in their retirement portfolio is their health. They understand the dollars and cents of it – that the personal and collective neglect of health will cost them extraordinary sums via taxes, health insurance, and out-of-pocket expenses. In other words, health, in one form or another, is the greatest expense most people will ever bear.

How has TheissCare Impacted Your Life? 

So many have invested time and money on health programs that, sadly, have yielded minimal lasting returns. Thus, my high-achievement clients are drawn by TheissCare’s guarantee of measurable results. I am very clear about what we offer because I know what works. If your current wellness program does not create higher set-points for your metabolism, lipolysis, and homeostasis, then you risk losing 90% of any lasting benefits. Unless a program is custom designed to meet your needs and monitored and adjusted throughout, you will simply not get the results you are looking for. Without this scientific personalization and tracking, for every hour you devote to your exercise and wellness program, you achieve only FIVE TO TEN MINUTES of lasting, measurable benefits. This is an unacceptable return on any investment!

We are living in a time of tremendous breakthroughs in every field. In order to take part in those evolving benefits, all of us are being forced to offload mistaken and limited concepts of the past. A truly motivating thought comes from motivational author Alvin Toffler, who wrote, “The illiterate of the 21st century will not be those who cannot read, but those who cannot learn, unlearn and relearn.”

I hope this article touches that part of your highest self that motivates you to grow – to take control of your energy, health, and life – because if you do not, someone called a health-care provider will! At this point, it’s still your choice…

Disease Progression – The 7 Stages of Disease

It takes energy to make energy – and that’s why our mental and physical laziness eventually leads to atrophy. The first step in atrophy is the body’s inefficiency to burn fat, leading to toxic fat – which is a major organic pollutant– which further inhibits the body from performing its natural function of regeneration of muscle mass and supplying energy. I am not a medical doctor, and I have not collected the scientific data to prove on a molecular level how degeneration takes place. However, I do see the empirical effects of diet and exercise on a daily basis. This is what I see.

The build up of toxins shows up in both the body and mind. Lethargy and depression are common in people whose systems are overworked with the process of storing and maintaining fat. Because I burn most all of my daily food-fuel, I sleep only 3-5 hours a night. I don’t need more sleep because my body metabolism is so efficient, and I don’t have all the pollution in my system. Therefore, my body doesn’t need to expend as much energy in constant detoxing. Constant digestion is a result of both overeating and improper diet. Digestion requires a significant amount of energy – which is thereby not available for metabolic efficiency. If your body can’t process enough toxins (in order to cleanse and heal itself), the body can’t be efficient at sustaining and re-creating itself. Thus, due to compromised systems, most people reach a state of atrophy well before their natural time.

When the blood, lymph nodes, and tissues of the body become toxic, the entire body is under stress. Tiredness and sluggishness are symptoms of the onset of this internal bodily stress. This negative physical state directly affects one’s mental and emotional condition, and this shows up as confliction, confusion, depression, lack of will power, and lack of creativity (which is a major concern of employers in the workplace).

When we need to heal ourselves of toxins, we sometimes create a fever in order to burn impurities in the system. Inflammation is the body’s most intense effort to cleanse itself. The root “itis” means inflammation. It’s kind of like smelling salts – even an unconscious person will wake up when smelling salts are used because the salts are such powerful irritants. Pain is the body’s most effective warning sign.

Inflammation, if unhealed, over time doesn’t allow the cells to communicate. This is what cancer is. Medical science is now recognizing that 80-90% of diseases come through internal and external environmental toxins. Cancer is not primarily genetic. Actually, life is only one thing – a controlled state of disease. If the body controls its constituent systems, one can live a happy and healthy life right up to the time of “natural” death. If our control mechanism fails, we lapse into disease and begin the slow-but-steady spiral downward into unnatural and premature death.

Disease never sneaks up and strikes us down. It takes a long time of neglect and repeated abuse of the body before disease takes over. Each stage progresses slowly and in a predictable manner. We can be in one of the stages of disease for weeks, months, or even years before we progress to the next stage. At any time during the first six stages, if the cause is stopped then the disease subsides and our health returns to normal. If drugs are used to stop the pain and discomfort, but avoids curing the underlying problem, then the disease will continue, even though we experience no pain, thus giving the false impression that the disease is diminishing. According to the latest research, here’s how the seven stages of disease progress.

#1 : Low Energy

Low Energy is the 1st stage of the 7 stages of disease progression

The first of the 7 stages of disease progression is low energy or enervation. The word enervation comes from the word energy, and energy is the essence of all life. Our whole existence depends on how much energy is available at any given time to fuel our trillions upon trillions of chemical reactions. Every one of those trillions of reactions requires a massive amount of energy.

Enervation: is a condition in which the body either is not generating sufficient energy for the task it must perform or the tasks the body must perform are greater then the normal energy supply can cope with. When this occurs the body becomes impaired and generates even less energy.

When less energy is available for bodily functions, including metabolism, toxins from metabolic waste start to build up in the cells of the body. A small amount of toxins in the body is normal. Problems arise when more toxins are being produced than eliminated. This toxification results in the further inability of the body to restore depleted energy, and the body starts to slow and shut down.

Since energy is restored when we sleep, the first warning sign that we are becoming enervated is that we will become tired and sluggish or require naps during the day or more sleep at night. Another sign that the body is in distress (trying to heal itself) is the loss of appetite. This loss of appetite can be seen through all stages of disease.

#2 : Toxic Build-Up

Toxic build-up is the 2nd stage of the 7 stages of disease progression

Toxic build up, or toxemia occurs when un-eliminated toxic material from trillions of metabolic process starts to saturate the blood, lymph nodes and tissues of the body. The body recognizes this situation must be remedied and attempts to cleanse itself and initiates a flushing-out of toxins.

1. The first sign of increased build up of toxins in the body is mere discomfort.
2. The second sign is further drain on the body’s energy supply, as the feeling of tiredness and sluggishness becomes more pronounced.

When the level of toxemia has reached the point where such toxins must be eliminated, the next stage of disease develops: fever. Fever is the universal sign that insufficient toxins are being removed. To prevent structural damage, the body increases its temperature to literally burn toxins. Fever is an activity of the body initiated for the express purpose of protecting itself.

Metabolism is therefore accelerated by increasing the amount of heat available, thus enhancing the healing process. The heat from fever is necessary to accelerate the elimination of toxins. Fever acts as a catalyst, which causes the toxins to be diluted and pass into the blood stream to the bowels, bladder, lungs and skin for elimination.

We can see fever in stages 2-7 of disease.

#3 : Irritation

Irritation is the 3rd stage of the 7 stages of disease progression

The third of the 7 stages of disease progression is designed to make us more aware that toxins are rising to a higher level and is an attempt to convince us to remedy the situation. Irritation isn’t usually so painful that we want to call the doctor, but it is so uncomfortable that it becomes harder to ignore.

Irritation is a condition in which the body sets its defensive mechanism into motion and speeds up its internal activities in order to unload stored-up toxins.

The two most common signs of irritation are the urge to urinate or have a bowel movement. If these two signs are ignored, it becomes so painful that your body will relieve itself. Another warning sign of irritation and toxemia is itchiness. The skin is largest organ of elimination, made up of 4 billion pores. So, if any part of the body becomes itchy, it is a classic sign that toxins are being removed.

At this stage of disease progression, one may experience nausea, queasiness, tickling of the nose, uneasiness, or feel short-tempered, aggravated, and nervous. We feel irritated because our bodies are in a state of irritation. It’s just that simple. Depression, anxiety, continued worry, stress, headaches, and even minor aches and pains are symptoms. Difficulty falling asleep or staying asleep become challenges… and then, of course, there’s the red flashing warning sign – weight gain.

When the effects of enervation, toxemia, and irritation are ignored long enough, and the toxic residue that started the whole process in motion builds to an even higher concentration, the fourth stage of disease progression results.

#4 : Inflammation

Inflammation is the 4th stage of the 7 stages of disease progression

The fourth stage of disease progression is inflammation. Inflammation is the body’s most intense effort to cleanse and restore itself. When this process occurs, you become keenly aware that a problem exists, for it involves pain.

Pain is designed to protect us and warn us when our health and perhaps very existence are at risk. Pain is the body’s most effective warning sign.

By the time of inflammation, the toxins in the system have usually concentrated in a particular organ or area of the body – for a massive eliminative effort. The area becomes inflamed due to the constant irritation from toxic material.

When inflammation exists, we are diagnosed with one or more of the “itises.” “Itises” used at the end of organ-words means inflammation.

• Tonsillitis: inflammation of the tonsils
• Appendicitis: inflammation of the appendices
• Hepatitis: inflammation of the liver
• Nephritis: inflammation of kidneys
• Arthritis: inflammation of the joints
• Colitis: inflammation of the colon
• Rhinitis: inflammation of the sinus cavity
• Dermatitis: inflammation of the skin
• Lymphadenitis: inflammation of the lymph nodes or glands

Swollen lymph nodes or glands are the bodies’ most obvious warning signs that a cleansing of built-up toxins is overdue.

At this point in the 7 stages of disease, if corrective actions are taken to lower the toxic levels, the body will clear itself of these harmful toxins. However, people often don’t take action at this critical time, and some will take drugs – which suppress the painful symptoms, without addressing the underlining problems. Therefore, toxicity will continue to increase until secondary organs become affected – not only by the primary toxins, but from the additional toxins created by the drugs.

Stage four of disease progression is a pivotal juncture. Action taken at this point determines whether or not one is going to recover and return to a state of health or fall deeper into the disease.

#5 : Ulceration

Ulceration is the 5th stage of the 7 stages of disease progression

The fifth stage in the 7 stages of disease progression is ulceration. Ulceration occurs when the body has been under assault for extended periods of time and massive amounts of cells and tissue are being destroyed.

Ulceration is intensely painful because of exposed nerves. For example, a stomach ulcer – a hole in the stomach – can be literally opened up, releasing toxins directly onto the exposed nerves. Another form of ulceration is canker sores on the mouth.

While the body may use an ulcer as an outlet to rid itself of toxins, the body will still heal the ulcer if the level of toxemia is sufficiently lowered.

#6 : Scarring

Scarring is the 6th stage of the 7 stages of disease progression

Induration is a form of scarring, which is hardening of tissues or the filling- in of tissue where it has been lost, such as with an ulcer.

Though painful, this hardening has real direction and purpose. The toxic material that is threatening the well-being of the body is encapsulated in a sac of hardened tissue. This is the body’s way of quarantining toxic material, holding it in one place so it will not spread freely throughout the body. The sac is a type of tumor and is often diagnosed as cancer when, in fact, no cancer exists.

Induration is the last stage during which the body is still in control of its cells. If the destructive practices that brought matters to this stage are allowed to continue, cells will start to go crazy. They will become parasites, living off whatever nutrients they can obtain, but contributing nothing to the body in return. This constant poisoning has at last alerted the genetic encoding system, and cells become wild and disorganized. This condition is called cancer.

#7 : Cancer

Cancer is the 7th stage of the 7 stages of disease progression

Cancer is the end point in the long evolution of disease progression, and if the original toxins that caused it remain in sufficient density, stage 7 of the stage of disease is usually fatal. At this point, body vitality is at a very low level. Cells are no longer under the brain’s control, but are multiplying wildly in an unorganized manner.

In the best of circumstances, employing a healthy regimen, cancer can be arrested and reversed; it usually takes a diligent, concentrated effort to eradicate. Thus, cancer is often the toxic and unnatural end to toxic and unnatural living. Some people cannot avoid the disease, but many can avoid or postpone it. As terrible and dreaded as the cancer is, the essential fact is – in the first stages – cancer is usually a matter of choice!



The Aging Process… Chronological Aging versus Biological Aging. Can you reverse the aging process?

None of us like getting old. The process of aging is annoying, uncomfortable, and it just plain hurts. New research on aging shows that regardless of how old you are, you can greatly improve or reverse the aging process. Let’s begin with some definitions. What is chronological aging and what is biological aging?

Chronological Age

Chronological Age is measured by earth revolutions around the sun. This is the one we’re all most familiar with. Because it’s easy and familiar, everyone has a chronological age. Many tests and programs are based around it.

Is this really a good measure of age in a technologically evolving world?

There are big problems with measuring age chronologically. All it says is you were born x years, or earth-sun rotations, ago. Considering that the aging process is different for everyone, biological aging would be a better method of measure

Biological Age

Biological aging can be reversed with specific exercise & nutrition.

Biological Age is defined as an individual’s development based on biomarkers. A biomarker is a recordable molecular or cellular event. Here we’re looking at the individuals as they are, not necessarily when they were born. This is biological aging.

Humans, in most cases, follow the same biological path. For example, the easiest one that comes to mind is the beginning of puberty. More complicated ones exist, such as increases and decreases in human growth hormone, myelination events in the brain, and the degradation of certain tissues as you get older.

The great news is, we can significantly slow or even reverse biological aging through a combination of specific exercise, nutrition, and lifestyle. But what is the combination that will deliver the optimum results? Can we reverse the aging process by 10, 20, 30 or more biological years? Again, the answer is YES.

The 5 Theories of The Aging Process

In the fight against aging, most of us need all the help we can get. Little do we know that there are many factors that can contribute to aging that we can work to control.

The following are the five theories anti-aging experts attribute to its causes, amplification and prevention.

1. Inflammation The activation of the immune system—due to an infection, allergen or toxin—leads to internal inflammation at the cellular level. Poor nutrition, too little sleep, and radiation are common culprits of low-grade inflammation, which has been linked to arthritis, cancer, Alzheimer’s disease and heart disease.
2. Lifestyle What we eat (too much sugar, fat and sodium), drink (too much soda, juice, etc.), do (get overstressed, work too much), don’t do (exercise or sleep enough), and what we expose ourselves to can speed up the aging process and the development of chronic diseases.
3. Hormones Levels of estrogen, progesterone, testosterone, DHEA, thyroid and/or human growth hormone drop as we age. But by increasing these all-important biochemicals, it may be possible to improve health and forestall the aging process. A controversial approach, hormone therapy, requires oversight by an experienced physician.
4. Antioxidants Call it the “rusting” theory. As we get older, we’re subject to oxidative stress, the byproduct of free-radical damage, a natural process in which unstable molecules disrupt cell and tissue functioning. Antioxidants such as vitamins A, C, and E, glutathione and alpha lipoic acid can help protect cells.
5. Detoxification When the body can’t rid itself of toxins, including high amounts of sugar, trans fat, mercury and chemicals we ingest from our food, its equilibrium is impaired, leading to fatigue, poor skin, heart disease, cancer and more. Detoxification and inflammation are closely linked.

Cutting Edge Research on Aging

A groundbreaking study called the New Zealand Longitudinal Study of Aging confirms people age at different rates. It turns out your chronological age is just a number! More importantly, your biological age can reveal a great deal about your general health and the rate at which you are aging. This study was different than other research on aging. The scientists’ objective was to reveal more about the aging process in younger people, and therefore provide a foundation for devising preventative therapies for age-related diseases.

During this research on aging nearly 1,000 subjects born in New Zealand in 1972 and 1973 were measured for 18 different biological markers over a period of almost 40 years. Each marker is a piece of the aging puzzle. The ‘health’ of each participant’s pulmonary, periodontal, cardiovascular, renal, hepatic, and immune systems were assessed using these biomarkers. With these results, researchers calculated a biological age for each participant and then compared the changes in these measurements over time, yielding a quantified pace of aging.

The majority of the research on aging participants had biological ages similar to their chronological age. But here is the important part. Some participants were found to have aged as much as 3 years physiologically over the course of just one calendar year. Scientists also found participants with an accelerated rate of aging performed worse on physical and cognitive ability assessments.

It’s up to you to reverse the effects of the biological aging process

The common saying, “you’re as old (or young) as you feel,” was confirmed by the study’s results. Participants with an older biological age perceived themselves to be in worse health than their biologically younger peers.

A big challenge in assessing aging are the compound results caused by cumulative life experiences. For doctors and scientists, it’s nearly impossible to determine whether lifestyle, stress, medical history, or other circumstances are individually responsible for many age-related diseases.

Ultimately, it’s a combination of all these factors that either ages you prematurely or keeps you healthy and prevents illnesses now and in the future. This is precisely why so many biomarkers were used in the study and why multiple beneficial lifestyle choices typically have a synergistic effect on your overall health.

This study will have significant implications on further research to prevent aging, which will help us not only increase our lifespans, but more importantly, increase our health span, or “the years of life lived without disease and disability.” Living longer doesn’t help us much if we’re too sick to fully enjoy the extra years we have. Making proactive decisions about your health now can have lasting positive effects this new research on aging shows.

This is all good news, but it’s just the beginning. Most people are either too lazy or not worried enough to change their behavior and routine. In my next article, I’ll be talking about the most common major age-related health issues.

What Our Clients Say…

I Can Reverse the Effects of Middle Age

Dear Brian,

How to reverse the biological aging process at 51

I can’t thank you enough for providing me with the support and training that has given me improved health, energy, focus and most importantly the knowledge that I can reverse the effects of middle age.

Before joining your program I believed that I would need to live with high blood pressure, feeling winded after climbing stairs, lack of energy and just feeling like an old man at 51 years of age. After just 4 weeks of training my blood pressure was normal, I could climb stairs without feeling winded and I felt 20 years younger. It was truly amazing!

Brian, thanks again to you and your professional staff for all that you done for my health, my family and my business by keeping me on track.

Best regards to you and your staff,

Jeff

Stopping the Aging Process in it’s Tracks – The New 50

My Health is Now a Cherished Commodity

Dear Brian,

How to reverse the biological aging process

Thank you for the gift of new life. Because of your very special “Gift” and your unique understanding of the human body, you accomplished what I thought would be impossible! After having gained so much weight and having various other unsolvable medical problems as well. I had given up hope that anything or anyone could help. I was pleasantly surprised with what you were able to do with this body of mine, both physically and mentally.

I even got to the point that I looked forward to exercising, me, the person that wouldn’t go to the gym! Brian, you are the most energetic. uplifting and positive person I have ever met, and that definitely worked for me. The special attention given me by your entire staff was so positive that , along with all your incredible knowledge about the body, I am a different person today. For that, I will be eternally grateful. I feel great and more than that. I am a different person. I stay excited about everything now. Everyone notices the change in me, and my husband loves it too. My health, something I took for granted before becoming almost bedridden, is now a cherished commodity.

Thank you for getting me started on the road to a longer and healthier life. You are a jewel.

Best Wishes Always,

Corinne

Incorporating these natural supplements into your daily life can slow and even reverse the signs of aging

You can slow or reverse the signs of aging starting today through the use of these 10 natural supplements. For maximum effect, the key is to incorporate all of these natural supplements into your daily life. These are natural organic solutions that will help reverse the aging process. When combined with an organic diet, reduced UV exposure, plenty of water, and adequate sleep, you have a great chance at reversing the signs of aging.

10 Natural Supplements to Reverse the Signs of Aging

1. Glucosamine

Benefits of Glucosamine – Protects against: Fine lines and sagging skin
Although there’s more research on the amino acid as a topical ingredient, a study published in the Journal of Dermatologic Treatment showed a 34% reduction in visible wrinkles and fine lines in participants who ingested it. A review of the benefits of glucosamine in The Journal of Cosmetic Dermatology suggested it can accelerate wound healing, improve skin hydration, and decrease wrinkles when taken as a natural supplement.
Recommended dose of Glucosamine: 1,500 mg per day

2. Coenzyme Q10

Benefits of Coenzyme Q10 – Protects against: Wrinkles
What is coenzyme q10? Similar to vitamins C and E, coenzyme Q10 is a nutrient that can help contribute to the overall health and appearance of your skin. Coenzyme Q10 has also shown promise as a particularly effective youth-booster: In a Japanese trial, adults who took oral coenzyme Q10 reported a reduction in wrinkle depth, volume, and area after just two weeks.
Recommended dose of Coenzyme Q10: 200 mg per day

3. Vitamin C

Benefits of Vitamin C – Protects against: Wrinkles and dullness
The benefits of oral and topical vitamin C have been shown in clinical studies to decrease oxidative stress in cells, which helps cells to grow normally. This helps cells regenerate and produce healthier skin, pumping the brakes on wrinkles and making your complexion more vibrant. Vitamin C also has been clinically shown to improve lipoprotein as well as antioxidant activity of serum being enhanced with the elevation of Vitamin C dosage.
Recommended dose of Vitamin C: 1250 mg per day

4. Vitamin E

Benefits of Vitamin E – Protects against: Environmental skin damage and dullness
“Research shows that vitamin E has antioxidant and anti-inflammatory properties,” Goldenberg says. Both factors are important and show that vitamin E benefits skin regeneration and cell turnover, the process in which dead skin cells slough off and healthier, more radiant skin cells take their place. Goldenberg says vitamin E also protects skin from wrinkle-forming UV radiation and environmental damage.
Recommended dose of Vitamin E: 200 IU per day

5. Polypodium Leucotomos Extract (PLE)

Benefits of Polypodium Leucotomos Extract – Protects against: Sun damage, discoloration, and sagging skin
In a Journal of Photochemistry and Photobiology study, Polypodium Leucotomos Extract helped preserve human skin’s fibroblasts, which build and restore collagen to help combat wrinkles and sagging skin.
Recommended dose of Polypodium Leucotomos Extract: 500 mg before sun exposure

6. Telomerase

Benefits of Telomerase – Protects against: Natural shortening of telomeres essential to cell replication
Telomerase is a natural enzyme that is an anti-aging supplement created to increase the length of a telomere (or telomeres). Telomeres are the tips of the chromosomes which shrink in size as the cell divides; anti-aging doctors believe that the longer the telomeres, the longer a person will live. Telomerase increases the size of the telomeres which rejuvenates everything from the skin to all other organs, thus leading a person to life extension
Recommended dose of Telomerase: 250 – 1000 Units

7. Fish Oil or Omega 3 Fish Oil

Benefits of Omega 3 Fish Oil – Protects against: Heart disease and stroke, inflammation
Fish oil is very popular due to its high concentration of omega 3 fatty acids and its other benefits as an anti-aging system. Fish oil (or omega 3 fish oil) improves skin suppleness. It’s also known to be a great way to naturally treat arthritis and forms of inflammation within the body.
Recommended dose of Omega 3 Fish Oil: 1000-1500 mg daily

8. Alpha-Lipoic Acid

Benefits of Alpha-Lipoic Acid – Protects against: Cell oxidation and blood sugar balance
Alpha-Lipoic Acid is fat and water soluble . ALA is a powerful anti-oxidant and it helps control the level of glucose in the body. It also helps lower high levels of sugar in the blood and is beneficial in fighting Type II diabetes. Alpha-lipoic acid is one of the best anti-aging supplements. There’s some early evidence that long-term use of alpha-lipoic acid might help with the symptoms of dementia. Other studies suggest that an alpha-lipoic acid cream might help skin damage related to aging. However, more research needs to be done.
Recommended dose of Alpha-Lipoic Acid: 500-1200 mg daily

9. Glutathione

Benefits of Glutathione – Protects against: Cell oxidation and blood sugar balance
Glutathione is one of the most powerful anti-aging antioxidants around; it is produced in the body by the amino acids: cysteine, glutamic acid, and glycine; glutathione is one of the best anti-aging supplements because it is a great way to detoxify the body, maintain the body’s red blood cells and protect white blood cells
Recommended dose of Glutathione: 250 – 500 mg daily

10. DHEA

Benefits of DHEA – Protects against: Cell oxidation, inflammation, wrinkling, adrenal response
DHEA is a naturally occurring anti-aging hormone (like melatonin and human growth hormones) secreted by the adrenal gland. DHEA regulates the male and female sex hormones, androgen and estrogen. As a result, DHEA can impact a person’s rate of aging, including skin wrinkling and maintaining collagen for a longer period of time
Recommended dose of DHEA: 25-200 mg daily as advised medically

There are other natural supplements that can be added to this list as well. These ten will give you a great start toward reversing the effects of natural aging. You can take full advantage of these natural supplements by combining them with an anti-oxidant rich organic diet, and minimum UV exposure. Remember to drink plenty of water and get adequate sleep daily, as well.

Most DNA molecules consist of two biopolymer strands coiled around each other to form a double helix

We’re on the edge of being able to control or reverse the rate at which we age. There are exciting new technologies, revolving around telomeres and aging, that when combined with a carefully designed exercise and fitness plan, can clearly reduce and even reverse the aging process.

Dr. George Church

Introducing the Harvard Pioneer of CRISPR, Dr. George Church. He is a highly distinguished professor of genetics and major figure at Harvard Medical School and in science worldwide. He is a pioneer in the area of genome engineering and the development of gene editing tools based on the CRISPR/Cas9 system (referred to as CRISPR here).

In December 2015, Dr. Church presented a talk highlighting that aging seems to be controlled to a large extent by the action of a rather small subset of your genes, and especially by master genes that control large numbers of other genes.

Your genes are areas of your DNA that determine eye color, hair color, sex, height, and other characteristics of your body. It is becoming more and more clear that genes also determine how you age.

Dr. Church described how science has now advanced to the point where the activity of your genes, whether the genes are “turned on” (expressed) or “turned off” (repressed, or down-regulated,) can increasingly be controlled, and not just in a test tube, but in whole bodies, and even in the brain.

Reducing or Reversing the Aging Process

CRISPR – Clustered Regularly Interspaced Short Palindromic Repeats

Dr. Church’s focus is on CRISPR technology, which is a relatively new and particularly powerful method for adjusting gene activity in many different ways. It can even be applied for “editing”, or changing genes, which can be used to correct deleterious mutations, or to create deliberate mutations that can have good effects (such as in knocking out the effects of pro-aging genes).

The implication is very clear: If aging is controlled by master genes, and if the activity of such genes can now be intentionally controlled, then we are beginning to approach the regulating and reversing of aging on a very fundamental level. The same technology can be applied to the correction of many diseases as well, whether age-related or not.

Dr. Church wants to make the control of aging a practical reality, and soon. In an interview with the Washington Post at the beginning of December 2015, Dr. Church said his lab is already reversing aging in mice. He has already been able to reverse aging in human cells using CRISPR technology, and expects the first clinical trials of this technology to begin within as little as one year and that human applications may only be a few years away.

As exciting as this is, it’s not the only alternative when it comes to what’s happening at the cellular level. A second technology is currently available. It focuses on telomere lengthening. Telomeres are directly related to aging.

Nobel Science for Anti-Aging

Telomeres are the protective caps on the ends of the strands of DNA called chromosomes, which house our genomes. In young humans, telomeres are about 8,000-10,000 nucleotides long. They shorten with each cell division and when they reach a critical length the cell stops dividing or dies.

A telomere is a region of repetitive nucleotide sequences at each end of a chromosome

Telomeres therefore act as a kind of molecular clock that tells a cell how old it is. Our cells also have a special enzyme called telomerase that rebuilds telomeres causing telomere lengthening. Cells with lots of telomerase can live much longer, and those without it die more quickly. Discovering how this all worked was a tremendous scientific achievement, for which Elizabeth Blackburn, Carol Greider and Jack Szostak received the 2009 Nobel Prize.

If we know the epigenetic state of all these different cells, no matter how many years apart they are, it only takes a few days to reprogram a cell and duplicate the effects of decades of slow change in the body, or reverse those effects. So in principle we could turn a young cell into an old one or an old cell into a young one because the only difference between them is epigenetics, or gene expression.

Turning Back the Internal Clock and Reversing Aging

Turning back the internal clock to reverse aging

“Now we have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life,” said Helen Blau, PhD, professor of microbiology and immunology at Stanford and director of the university’s Baxter Laboratory for Stem Cell Biology. “Telomere lengthening greatly increases the number of cells available for studies such as drug testing or disease modeling.”

The Stanford researchers found that as few as three applications of the modified RNA over a period of a few days could significantly increase the length of the telomeres in cultured human muscle and skin cells. A 1,000 nucleotide addition represents more than a 10 percent increase in the length of the telomeres. These cells divided many more times in the culture dish than did untreated cells: about 28 more times for the skin cells, and about three more times for the muscle cells.

“This study is a first step toward the development of telomere lengthening to improve cell therapies and to possibly treat disorders of accelerated aging in humans,” said John Cooke, MD, PhD. Cooke, a co-author of the study, formerly was a professor of cardiovascular medicine at Stanford. He is now chair of cardiovascular sciences at the Houston Methodist Research Institute.

There are also implications for treating conditions of aging, such as diabetes and heart disease. This has really opened the doors to consider all types of potential uses of this therapy.” Ramunas, Yakubov, Cooke and Blau are inventors on patents for the use of modified RNA for telomere extension.